On this website, we constantly talk about how chemical contaminants hiding in foods, cosmetics and tap water are secretly causing everyone’s acne.
There’s no doubt that heavy metals like arsenic and supposedly healthy additives like fluoride are joining forces and fuelling the fires of the global acne pandemic…
…but one group we haven’t discussed yet is the naturally occurring plant toxins. Namely, the many varieties of mycotoxins, toxic bioweapons manufactured by mould species growing on contaminated foods.
Mycotoxin fact file
In nature, there are three broad groups of fungi: mushrooms, bacteria and mould. The latter two are locked in a never-ending war for dominance, raging for millions of years, and one of the mould’s key weapons in this war is mycotoxins.
Mycotoxins have the power to kill bacteria cells, and hence, many of the backbones of western medicine are based on them. Penicillin is a classic example, being based on Penicillium moulds before going on to save millions of lives.
But there’s a dark side too: that other mycotoxins have the ability to completely destroy your health. Examples include aflatoxins, ochratoxin, T2 toxins, fumonisins, zearalenones (which have potent estrogenic activity) and the relatively unknown deoxynivalenols. Consider, for example, the respiratory problems which inhabitants of old and disused buildings commonly have: mould spores are the classic culprit.
Why do we care about mycotoxins? Because the single biggest sources are foods contaminated with the moulds that produce them. Poor quality coffee, chocolate beer, wine, nuts and beans are all hotbeds of mycotoxins, with cocoa beans, for example, being contaminated during the earliest stages of sun drying on wooden platforms.
Nearly 100% of acne patients have mycotoxins in their bodies. At high levels, mycotoxins are just as dangerous as heavy metals like arsenic or mercury.
Consider the two most famous mycotoxins:
Ochratoxin A – primarily found in green coffee, cocoa products, nuts, dried fruits, and meat. Predominantly generated by the aspergillus and penicillium mould families. This mycotoxins is notorious for accumulating in the kidneys and causing gradual kidney failure, in humans, rats and birds alike. Ochratoxin A has an equally high affinity to the brain, and may contribute towards Alzheimer’s disease.
Aflatoxin B1 – this mycotoxin is classified as a group 1a carcinogen by the International Agency for Research on Cancer (the worst of the worst). Impoverished Asians and Africans whose foods are heavily contaminated with aflatoxins have some of the world’s highest liver cancer rates.
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Aflatoxin B is found in cocoa, coffee, nuts and most notoriously peanuts. It’s also rampant in animals feed, and even has the ability to penetrate human skin. Aflatoxin B is manufactured by two main species of mould – aspergillus parasitic and aspergillus flavus.
The rising shadow of mycotoxins
Those are the two big beasts of mycotoxins, but there’s dozens of others which can destroy human health. The WHO is particularly concerned these days. It began back in 1991, when they gave aflatoxin B a tolerable weekly limit of 11ng per kg of bodyweight.
By 1997, the WHO committee had concluded that aflatoxins were strongly carcinogenic. By 2007, slashing mycotoxins in food and animal feed (particularly aflatoxin B) had become an official plank of the WHO’s global strategy. 100 countries encompassing 85% of the world’s human population regulate mycotoxin levels in foods, with the EU being particularly tight.
Consumers are increasingly concerned as well; coffee lovers everywhere are now ditching their poor quality instant beans. The famous Bulletproof coffee recipe, swimming with butter, is popular partially because of its avowed absence of any mycotoxins. Fitness fanatics in paleo and primal circles are arguing right now over whether mycotoxin disqualify coffee and chocolate completely.
But do they cause acne?
Perhaps the most notorious danger of mycotoxins is disrupting the immune system.
Anyone with a sensitivity will know the classic symptoms – joint pain, total disruption of mental concentration, fatigue. Those are also of the classic signs of chronic inflammation, the worst disease behind acne.
ONE: one classic villain behind indoor mould contamination in old dilapidated buildings is s.chartarum and the trichothecene mycotoxins it produces. In this 2009 study, purified trichothecene strongly enhanced the pro-inflammatory chemicals interleukin-1beta and interleukin-8. Roridin A, verrucarin A, and T-2 toxin did exactly the same. Interleukin-8 has been liked to acne in several studies.
TWO – this 1987 study analysed another thrichothecene mycotoxin (a dangerous and heavily studied group) called fusarenon-x. The twist is that the mycotoxin was merely used to create inflammation in the first place – the real goal was testing an anti-inflammatory remedy. Clearly then, its inflammatory powers are well established.
THREE – in human nasal cells, exposure to ochratoxin A massively increased both interleukin-6 and interleukin-8, two of the classic inflammatory chemicals behind acne. The scientists concluded that “the ubiquitous mycotoxin OTA has a strong pro-inflammatory effect… in nasal mucosa” (2012 study).
FOUR – this time, scientists discovered that OTA specifically increased the activity of NF-KappaB and COX2, a pair of of inflammatory master molecules which control dozens of smaller inflammatory chemicals. They concluded that “these results confirm the pro inflammatory effect of ochratoxin A by itself” (2008 study).
FIVE – after treating white blood cells with aflatoxin B for 72 hours, the pro-inflammatory and indeed pro-acne chemical IL-6 rose substantially. Meanwhile, the anti-inflammatory chemical interleukin-10 fell (2009 study).
SIX – after applying aflatoxin B to rat liver cells, their TNF-a, IL-6 and Il-8 levels all shot upwards (2014 study). As they put it: “the liver from the AFB1-treated rats showed over expression of pro-inflammatory cytokines”.
Chronic inflammation is the joint biggest villain behind acne, and mycotoxins fuel it massively. Without inflammation, your skin pores never swell up, redden, and transform into acne.
Mycotoxins are linked to oxidative stress
The second root cause of acne is oxidative stress, when your body is overrun with destabilizing, glow-snatching free radicals
Deactivating free radicals depletes your precious antioxidants – including vitamin A, vitamin C, vitamin E, glutathione and superoxide dismutase. All antioxidants are vital for clearing acne, and some have important side gigs, such as vitamin C for stress hormones, and vitamin A for controlling oily skin.
It seems that mycotoxins are a chief villain behind oxidative stress:
ONE: after several weeks of continuous aflatoxin B1 feeding, a group of rats had significantly elevated bloodstream radicals. Meanwhile, superoxide dimutase fell sharply, one of the body’s main homemade antioxidants (2015 study).
TWO: this review analysed many of aflatoxin B1’s side effects, and concluded that “oxidative stress… may be one of the underlining mechanisms for AFB1-induced cell injury and DNA… damages”.
THREE: exposing cells to ochratoxin A led to a surge in reactive oxygen species (2002 study), accompanied by a massive depletion of glutathione levels. Glutathione is the main antioxidant which your body manufactures itself, and acne patients often have low levels.
FOUR – after 14 days, OTA substantially increased oxidative stress in the kidneys of rats. Furthermore, there was a 44% decline in glutathione levels (2013 study). That’s a colossal reduction in acne-clearing antioxidants.
FIVE – in rats, ochratoxin A increased almost all parameters of oxidative stress, particularly serum malondialdehyde, an important lipid peroxide (free radical formed from fat tissues). Another mycotoxin, fumonisin B-1, also increased oxidative stress when combined with OTA (2007 study).
The evidence that mycotoxins increase the oxidative stress behind acne is rock solid. There’s at least 10 other studies which I didn’t include here.
Are mycotoxins a real culprit behind acne?
It’s clear that mycotoxins have the power to worsen acne, but what’s lucky is that levels are tiny even in the most contaminated foods.
For example, one European study found that among Spanish people, ochratoxin A intake from foods was just 3% of the European Food Safety Authority’s safe limit. Another study on Europeans found that drinking 4 cups of coffee per day contributed only 2% of the WHO’s daily exposure limit.
The coffee wasn’t pristine quality either; it was a simple cup that any caffeine-loving worker might enjoy at the local drive through.
The truth is that mycotoxins are unavoidable; one study found that nearly 100% of humans tested contained them. However, they’re generally only harmful in severe cases of contamination, e.g., dirt cheap coffee, or chocolate sourced from corrupt cocoa farmers with dodgy drying practises.
Generally, I don’t recommend following the advice of health bodies like the FDA blindly. Look at the acne-causing menace BPA. For years, they insisted that the small amounts in milk bottles were safe, before reality hit home when said children grew up with far low IQ scores.
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That said, there are no studies I know of suggesting harm from low levels of mycotoxins. You evolved your detoxification systems for a good reason. Almost all plants have natural defensive toxins, including glycoalkaloids in potatoes, tomatine in tomatoes, and oxalates in sweet potatoes. Yet those foods are still healthy because your detoxification system is constantly ticking away.
Secondly, many of the classic mycotoxin foods are packed with acne nutrients that counteract the damage.
In this study, scientists fed rats either ochratoxin A, or OTA combined with vitamin E, vitamin A and vitamin C. The nutrients totally negated the oxidative stress. Likewise, this study discovered that catechin antioxidants from tea blunted the harm from mycotoxins nicely.
Coffee, for example, is statistically second for mould contamination, yet is also the average American’s single biggest antioxidant source. In this study and this study, both tomatoes and liquorice protected against the glutathione depletion caused by ingesting mycotoxins.
The lowdown on mycotoxin contaminated foods
Coffee – coffee is most notoriously covered with ochratoxin A and fusarium mycotoxins. Coffee beans growing at humid, low altitude locations are more susceptible to mycotoxin mould overgrowth. However, the reassuring studies we discussed earlier speak for themselves, and here’s three more…
ONE: 20 of 60 green coffee bean samples from Brazil contained ochratoxin A at low levels (2003 study).
TWO: just 8 out of 30 roasted coffee contained ochratoxin A, and far higher contamination rates were observed in chillies (2013 study).
THREE: of 40 coffee brews made from commercially available coffee beans, only 18 contained ochratoxin A (1995 study).
Contamination is hardly rampant. Even when mycotoxins are present, the levels are far too tiny to cause acne, and coffee’s endless antioxidants like caffeic acid will surely outweigh them.
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Furthermore, modern day coffee farmers are well aware of the mycotoxin problem. Coffee is now assigned a quality score which is partially based on the mycotoxins count. Contamination now means lost profit, as the worst beans are discarded. Hence, farmers use special techniques like wet processing, which was shown here to reduce mycotoxin levels substantially.
Roasting coffee beans reduces the mycotoxin levels by between 42 and 55%, according to this study. Another study found 69.93% falls after 2.5 to 10 minutes of roasting.
The only serious mycotoxin reservoirs are instant and decaffeinated coffee brands. Instant coffee is typically made from the cheapest, lowest quality beans around, while decaf has one simple problem: caffeine is the coffee bean’s natural antifungal agent. Its entire job is to ward off poisonous moulds and disease. For acne-friendly decaffeinated coffee, a more expensive brand is a must.
Cocoa – handling is key with cocoa beans. All standard chocolate products have to be fermented first, both to reduce toxins like lectins and to craft the perfect chocolatey flavour we all know and love.
However, this also introduces moisture levels of around 40-50%, a perfect oasis for moulds to breed in. The most prominent strain is aspergillus flavus. Compared with coffee, cocoa is a safe haven for aflatoxin B1 and also cyclopiazonic acid (CPA). Apparently, 64.1% of a.flavus moulds produce aflatoxins and 34.2% produce CPA.
Next, the cocoa beans are sundried to bring the beans back down to 6-7% moisture. This usually takes a week, but in damp and cloudy weather conditions, it can take four. Mycotoxin moulds have a low tolerance for dryness, so the longer this sun-drying procedure takes, the greater their opportunity.
Furthermore, cocoa beans are often dried on wooden platforms, a source of the mycotoxin-producing fungi inoculum. Some producers sun dry cocoa in very thin layers, which encourages mould multiplication by increasing oxygen levels and destroying antifungal acids in the bean like acetic acid.
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In short, the opportunities for cocoa beans to get infected are plentiful. However, it’s an identical situation to coffee; while one study found that 50% of cocoa beans contained ochratoxin A after sun drying, the levels in each were very low. In fact, 50% was a high outlier; most studies find less than 20%.
Roasting cocoa beans decreased the mycotoxin levels by 24.40% in one study, and by 17% in another. A study from 2002 concluded that cocoa products contribute just 5% of total European ochratoxin exposure.
Furthermore, cocoa beans are also winnowed to remove the cocoa bean shell (the testa), the place where many fungal strains concentrate, particularly ochratoxin A. In finished cocoa nibs and chocolate, a maximum of just 1-1.5% testa residue is allowed. Mechanical shelling removes 48% of the OTA and hand shelling removes between 50 and 100%.
The best cocoa product then? Mycotoxin regulations are stricter in Europe compared to the USA, meaning that brands like Lindt are very clean. Raw chocolate is usually more contaminated as it isn’t roasted, but is still fermented (contrary to popular belief). The country of origin is also important, with Ivory Coast and Nigerian cocoa beans having the highest mycotoxin counts…
…but even in those circumstances, top quality dark chocolate (85% plus is best) is almost certainly safe for acne. Cocoa powder is jam packed with antioxidants, and in this study, cocoa polyphenols were specifically found to defend against mycotoxins.
Peanuts – your strategy here couldn’t be simpler: buy organic peanuts which are completely fresh. Peanuts are notorious for aflatoxin contamination if improperly handed. Like cocoa or coffee, they’re generally free from moulds when produced by reputable farms.
Wine and beer – a confirmed but insignificant source of mycotoxins. In this study, 30 beers and 30 wines were analysed, but only 5 and 2 samples respectively contained mycotoxins. The levels were tiny too. Note that beer isn’t a perfect beverage for acne, but is safe in moderation; alcohol itself is the same.
Conclusion
If you’re a proud coffee addict or a chocoholic in constant rehab then you can rest easy. Mycotoxins are nothing to worry about for acne as long as you dodge the most downmarket products.
The only serious worry is hypersensitivity. The symptoms can be almost anything (including acne), but the classics are fatigue, a dry mouth, brain fog, chronic pain, and digestive discomfort. These symptoms can occur instantly after drinking contaminated coffee, and only vanish after banishing the culprits forever.
Luckily though, humans and moulds have co-existed for million of years, and our bodies are genetically adapted to processing them. Your odds of being hypersensitive are very slim.
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Thanks for reading!
This is an excellent article. I have a loved one who i suspect of being hypersensitive to mycotoxins. She displays a number of the symptoms in your conclusion section. Please please please provide me with a link from which you got those symptoms. Thank you.
Hello Derrick, glad you found it useful. A dry mouth is not reported in many studies, but it’s a classic tell-tale sign among mycotoxin sensitive people. This study talks a lot about how myctoxoins might be behind chronic fatigue syndromes and there’s some interesting case studies in the link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920250/
This study talks about the neurological problems associated with heavy mycotoxin exposure. From the link: “respiratory signs (e.g., rhinorrhea, sinus tenderness, wheezing) were found in 64% of all patients, and physical signs and symptoms of neurological dysfunction (e.g., inability to stand on the toes or to walk a straight line with eyes closed, as well as short-term memory loss) were identified in 70% of all patients”. As you can see, respiratory problems are common as well. http://www.ncbi.nlm.nih.gov/pubmed/15143852
If you want to know about the general symptoms of mycotoxin exposure then I’d recommend reading the first link. It’s a complete review of many different studies on mycotoxin exposure. From their conclusion: “the occupants of these environments (heavy with mycotoxins) experience chronic adverse health effects that range from upper and lower respiratory disease, central and peripheral neurological deficits, chronic fatigue type illness, among others”.
Good luck.
Richard